← Human Trials & Peer-Reviewed Studies
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.
Plain-language guide to PMID 28552588 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, immune system (general).
Key Facts
- PMID
- 28552588
- Journal
- The Journal of allergy and clinical immunology
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Hornsby E et al. (10 authors)
- DOI
- 10.1016/j.jaci.2017.02.039
- Registered trial
- NCT00920621
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of immune system (general) in this randomized controlled trial publication.
Programming of the immune system during fetal development can influence asthma-related risk factors and outcomes in later life.
Vitamin D is a well-recognized immune modulator, and deficiency of this nutrient during pregnancy is hypothesized to influence disease development in offspring.
Who Took Part
PubMed tags the participants as women only.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Responsiveness to the glucocorticoid dexamethasone was determined.
What Was Measured
Programming of the immune system during fetal development can influence asthma-related risk factors and outcomes in later life.
The subject headings attached to it are Biomarkers, Cholecalciferol, Cytokines, Dietary Supplements, Immune System, Immunity, Innate and Immunophenotyping.
Author keywords: Vitamin D, asthma, innate immunity and pregnancy.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with immune system (general).
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (The Journal of allergy and clinical immunology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Immune system (general) research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.