A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD.

In this randomized, double-blind, placebo-controlled trial, the researchers investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml).

Who Took Part

The abstract describes 120 patients taking part.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

What Was Measured

The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks.

Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers.

The subject headings attached to it are Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Dietary Supplements, Endothelium, Vascular, Interleukin-6 and Pulse Wave Analysis.

The authors tagged it with the keywords Vitamin D and chronic kidney disease.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 120 patients.

The publication is from 2017 (Journal of the American Society of Nephrology : JASN), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.