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Effect of endovascular coronary low-level laser therapy during angioplasty on the release of endothelin-1 and nitric oxide
Plain-language guide to PMID 28691417 (2017): randomized controlled trial study of Endothelin-1 in 52 subjects.
Key Facts
- PMID
- 28691417
- Journal
- Advances in clinical and experimental medicine : official organ Wroclaw Medical University
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Derkacz A et al. (6 authors)
- DOI
- 10.17219/acem/62535
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Endothelin-1.
The aim of the study was to evaluate the effect of LLLT applied during percutaneous coronary intervention (PCI) on the factors participating in the homeostasis of vascular tone - NO and endothelin-1.
Why It Was Studied
It may be postulated that low-level laser therapy (LLLT) can favorably influence the process of restenosis by affecting those factors.
Who Took Part
The abstract describes 52 subjects taking part.
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
The control group was 49 subjects with PCI only.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Endothelin-1 and who got the comparison, which limits bias.
The researchers assessed the concentration of nitrites/nitrates reflecting NO metabolism as well as endothelin-1 in both groups before PCI, and at 6 h, 12 h and 1 month after the procedure.
In addition, half a year after PCI, a follow-up angiography was performed.
What Was Measured
It may be postulated that low-level laser therapy (LLLT) can favorably influence the process of restenosis by affecting those factors.
Topics PubMed links to this paper include Coronary Stenosis, Endothelin-1, Low-Level Light Therapy, Nitric Oxide and Percutaneous Coronary Intervention.
The authors tagged it with the keywords coronary angioplasty, low-level laser therapy and restenosis.
What This Means in Plain Language
The paper is a randomized study of Endothelin-1 in 52 subjects.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2017 (Advances in clinical and experimental medicine : official organ Wroclaw Medical University), a journal based in Poland.
More context: the Endothelin-1 compound page, all human trials.
Our Notes on the Compound
Endothelin-1: A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.