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The effects of vitamin D supplementation on metabolic profiles and liver function in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials.

Plain-language guide to PMID 28751149 (2017): meta-analysis of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement), fatty liver & elevated liver enzymes.

Key Facts

PMID
28751149
Journal
Diabetes & metabolic syndrome
Year
2017
Study type
Meta-Analysis
Authors
Tabrizi R et al. (8 authors)
DOI
10.1016/j.dsx.2017.07.025

What This Paper Covers, in Plain Language

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in the context of fatty liver & elevated liver enzymes in this meta-analysis publication.

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the evidence on the effect of vitamin D supplementation on metabolic profiles in patients with non-alcoholic fatty liver disease (NAFLD).

Who the Included Studies Covered

Seven RCTs with 452 participants (227 patients and 225 controls) were included in the meta-analysis.

How the Review Was Done

The researchers systematically searched PubMed, EMBASE and five other databases to identify all RCTs investigating the association between vitamin D and NAFLD up until 5 October 2016.

What Was Measured

The subject headings attached to it are Blood Glucose, Dietary Supplements, Lipids, Liver, Non-alcoholic Fatty Liver Disease and Vitamin D.

The authors tagged it with the keywords Liver function, Meta-analysis, Metabolic profiles and Vitamin D supplement.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in people with fatty liver & elevated liver enzymes.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (Diabetes & metabolic syndrome), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, Fatty liver & elevated liver enzymes research.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.