Absolute Postoperative B-Type Natriuretic Peptide Concentrations, but Not Their General Trend, Are Associated With 12-Month, All-Cause Mortality After On-Pump Cardiac Surgery

What Was Tested

Researchers studied BNP (Nesiritide) in this observational study publication.

B-type natriuretic peptide (BNP) is a predictor of mortality after on-pump cardiac surgery.

However, previous limited and heterogeneous studies have focused on peak concentrations at 3 to 5 days after surgery and may not offer clinicians much help in early decision-making.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, both men and women.

The researchers included consecutive patients undergoing on-pump cardiac surgery in this observational, secondary analysis of prospectively collected data.

How the Study Was Run

The researchers analyzed biomarkers on the first and second postoperative day. ΔBNP was defined as BNP on the second postoperative day minus BNP on the first postoperative day.

The primary end point was 12-month, all-cause mortality.

The secondary end point was a composite of major adverse cardiac events (MACEs) at 12 months and/or all-cause mortality at 12 months.

MACE was defined as nonfatal cardiac arrest, myocardial infarction, and congestive heart failure.

The association between BNP and outcomes was examined by receiver operating characteristic curves, as well as univariate and multivariable logistic regression, adjusting for the EuroSCORE II, cross-clamp time, and first-postoperative-day troponin T.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Cardiac Surgical Procedures, Cohort Studies, Heart Diseases, Mortality, Natriuretic Peptide, Brain and Postoperative Complications.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide).

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2017 (Anesthesia and analgesia), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.