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Effectiveness of continuing nicotine replacement after a lapse: A randomized trial
Plain-language guide to PMID 28756042 (2018): placebo-controlled randomized controlled trial study of Therapeutic nicotine (patch, non-peptide).
Key Facts
- PMID
- 28756042
- Journal
- Addictive behaviors
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Hughes JR et al. (5 authors)
- DOI
- 10.1016/j.addbeh.2017.07.023
- Registered trial
- NCT01807871
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.
Four post-hoc analyses of prior trials found smokers using nicotine patch following a lapse were less likely to progress to relapse compared to those using a placebo patch following a lapse.
The researchers attempted a conceptual replication test of these results via a randomized trial of instructions to continue vs. stop nicotine patch after a lapse.
Who Took Part
By PubMed's age tags, the people studied were middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and placebo-controlled study.
The participants were allocated by chance, so the Therapeutic nicotine (patch, non-peptide) group and the comparison group should start out alike.
The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.
The researchers randomized smokers to receive instructions for and rationale for stopping vs. continuing patch after a lapse.
The messages were repeated before and after cessation and following lapses via counseling, phone and written instructions.
What Was Measured
The researchers attempted a conceptual replication test of these results via a randomized trial of instructions to continue vs. stop nicotine patch after a lapse.
PubMed files the paper under topics including Recurrence, Smoking Cessation, Tobacco Use Cessation Devices and Tobacco Use Disorder.
The authors tagged it with the keywords Lapse, Nicotine patch, Nicotine replacement and Relapse.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2018 (Addictive behaviors), a journal based in England.
More context: the Therapeutic nicotine (patch, non-peptide) compound page.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.