Nicotine pharmacokinetic profiles of the Tobacco Heating System 2.2, cigarettes and nicotine gum in Japanese smokers.

What Was Tested

The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.

Who Took Part

The study group was 62 subjects.

PubMed indexes the participants as adults, middle-aged adults and older adults.

In each study, one on the regular and one on the menthol variants of the THS and CC, both using Gum as reference, 62 subjects were randomized to four sequences: Sequence 1: THS - CC (n = 22); Sequence 2: CC - THS (n = 22); Sequence 3: THS - Gum (n = 9); Sequence 4: Gum - THS (n = 9).

How the Study Was Run

The design is described as randomized, open-label and crossover.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Everyone knew when Therapeutic nicotine (patch, non-peptide) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

In the crossover set-up each of the subjects took both Therapeutic nicotine (patch, non-peptide) and the comparison in turn, acting as their own control.

Plasma nicotine concentrations were measured in 16 blood samples collected over 24 h after single use.

What Was Measured

Topics PubMed links to this paper include Asian People, Japan, Nicotine, Nicotine Chewing Gum, Nicotinic Agonists, Nicotiana and Hot Temperature.

The authors tagged it with the keywords Cigarette, Menthol, Nicotine gum, Smoking, Smoking urges and THS.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Therapeutic nicotine (patch, non-peptide) in 62 subjects.

The publication is from 2017 (Regulatory toxicology and pharmacology : RTP), a journal based in Netherlands.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.