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Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period
Plain-language guide to PMID 28778281 (2017): randomized controlled trial study of hCG (human chorionic gonadotropin) in 20 women, endometriosis.
Key Facts
- PMID
- 28778281
- Journal
- Fertility and sterility
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Xiong Y et al. (8 authors)
- DOI
- 10.1016/j.fertnstert.2017.06.004
What This Study Did, in Plain Language
What Was Tested
Researchers studied hCG (human chorionic gonadotropin) in the context of endometriosis in this randomized controlled trial publication.
To investigate the effects of high P level on the day of hCG administration in IVF cycles on epigenetic modifications of endometrium in the peri-implantation period.
Who Took Part
According to the abstract, 20 women were involved.
PubMed indexes the participants as adults, women only.
Forty patients were recruited: 20 women with high P levels were compared with 20 women with normal P levels.
Endometrial tissues were collected 7 days after hCG administration in women with normal or high P levels on the day of hCG administration.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.
Immunohistochemical staining of DNA methylation (5-methylcytosine, 5-mC), histone methylation (H3K4me2/3, H3K9me2, H3K27me3), and histone acetylation (H3K4ac, H3K9ac) was performed.
What Was Measured
PubMed files the paper under topics including Biomarkers, Chorionic Gonadotropin, Embryo Implantation, Endometrium, Epigenesis, Genetic, Fertilization in Vitro and Genetic Markers.
The authors tagged it with the keywords epigenetics and progesterone.
What This Means in Plain Language
The paper is a randomized study of hCG (human chorionic gonadotropin) in 20 women in people with endometriosis.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Results are reported in around 10 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2017 (Fertility and sterility), a journal based in United States.
More context: the hCG (human chorionic gonadotropin) compound page, Endometriosis research.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.