← Human Trials & Peer-Reviewed Studies
Vitamin D and symptoms of depression in overweight or obese adults: A cross-sectional study and randomized placebo-controlled trial.
Plain-language guide to PMID 28803880 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 48 participants.
Key Facts
- PMID
- 28803880
- Journal
- The Journal of steroid biochemistry and molecular biology
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Mousa A et al. (4 authors)
- DOI
- 10.1016/j.jsbmb.2017.08.002
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Interventional analyses were performed on data from 48 participants (30M/18F) who completed the trial.
The researchers measured serum 25(OH)D concentrations; anthropometry: BMI, waist-to-hip ratio (WHR), % body fat (dual X-ray absorptiometry); and depressive symptoms using the Beck Depression Inventory (BDI) before and after intervention.
Who Took Part
The study group was 48 participants.
PubMed indexes the participants as young adults and adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
The researchers measured serum 25(OH)D concentrations; anthropometry: BMI, waist-to-hip ratio (WHR), % body fat (dual X-ray absorptiometry); and depressive symptoms using the Beck Depression Inventory (BDI) before and after intervention.
Data on dietary vitamin D intake (3-day food record), physical activity (international physical activity questionnaire), and sun exposure habits were collected using questionnaires.
Topics PubMed links to this paper include Cross-Sectional Studies, Depression, Dietary Supplements, Overweight, Vitamin D, Vitamin D Deficiency and Vitamins.
Author keywords: 25(OH)D, Obesity and Randomized trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 48 participants.
The publication is from 2018 (The Journal of steroid biochemistry and molecular biology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.