Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Thereafter, the researchers analyzed the influence of maternal pre- and postsupplement vitamin D concentrations on cluster membership.

Finally, the researchers used the metabolites driving the clustering of children to identify the dominant metabolic pathways that were influential in each cluster.Results: the researchers identified 3 clusters of children characterized by 1) high concentrations of fatty acids and amines and low maternal postsupplement vitamin D (mean ± SD; 27.5 ± 11.0 ng/mL), 2) high concentrations of amines, moderate concentrations of fatty acids, and normal maternal postsupplement vitamin D (34.0 ± 14.1 ng/mL), and 3) low concentrations of fatty acids, amines, and normal maternal postsupplement vitamin D (35.2 ± 15.9 ng/mL).

Who Took Part

The abstract describes 245 children taking part.

The age groups tagged for this paper are young children, young adults and adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The children were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Some children received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

What Was Measured

Topics PubMed links to this paper include Amines, Asthma, Child Health, Dietary Supplements, Disease Susceptibility, Fatty Acids and Inflammation.

Author keywords: airway inflammation, metabolomics, polyunsaturated fatty acids, prenatal programming and vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 245 children.

The publication is from 2017 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.