Intraoperative magnesium sulphate decreases agitation and pain in patients undergoing functional endoscopic surgery: A randomised double-blind study.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The current study investigated the potential role of magnesium sulphate in treatment of postoperative agitation following functional endoscopic sinus surgery.

Why It Was Studied

The current study was registered according to WHO and ICMJE standards on 7 January 2014, under registration number PACTR 201402000737691.

Who Took Part

According to the abstract, 312 patients were involved.

The age groups tagged for this paper are young adults and adults, both men and women.

ENT operating room, Menofia University Hospitals, Egypt.

A total of 312 adult patients (171 men and 141 women) were enrolled in the study.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

A randomised, double-blinded, placebo-controlled trial.

Eighteen patients (10 men and eight women) were excluded; data from 294 patients were analysed.

Inclusion criteria were age between 20 and 60 years, American Society of Anesthesiologists' physical status 1 or 2 scheduled for functional endoscopic sinus surgery.

Exclusion criteria were hypertension, cardiac ischaemia, cerebrovascular insufficiency, neuromuscular diseases, pregnancy, prolonged treatment with calcium-channel blockers, diabetic neuropathy or a known allergy to magnesium compounds.

In the postanaesthetic care unit (PACU), patients were assessed for agitation and pain using the Richmond agitation-sedation scale and numerical rating scale, respectively.

What Was Measured

The subject headings attached to it are Analgesics, Emergence Delirium, Endoscopy, Intraoperative Care, Length of Stay, Magnesium Sulfate and Postoperative Pain.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 312 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (European journal of anaesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.