Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis.

What Was Tested

This controlled clinical trial looks at Vitamin D, K2, Magnesium and Zinc in the context of rheumatoid arthritis.

The present study aimed to evaluate proinflammatory cytokine and vitamin D levels in rheumatoid arthritis (RA) and chronic periodontitis (CP) patients and healthy individuals before and after initial periodontal treatment.

Why It Was Studied

Clinical periodontal measurements were recorded and gingival crevicular fluid (GCF) and blood samples were recorded.

RA + CP and CP patients received nonsurgical periodontal treatment.

Who Took Part

According to the abstract, 17 patients were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Overall, 17 CP patients with RA (RA + CP), 18 systemically healthy CP patients (CP), and 18 healthy controls (C) were included.

What Was Measured

Clinical periodontal measurements were recorded and gingival crevicular fluid (GCF) and blood samples were recorded.

Vitamin D, tumor necrosis factor (TNF)-α, receptor activator of nuclear factor-KB ligand (RANKL), and OPG levels were determined in GCF and serum.

The subject headings attached to it are Arthritis, Rheumatoid, Case-Control Studies, Gingival Crevicular Fluid, Osteoprotegerin, Periodontitis, RANK Ligand and Tumor Necrosis Factor-alpha.

The authors tagged it with the keywords RANKL/OPG, chronic periodontitis, rheumatoid arthritis and vitamin D.

What This Means in Plain Language

This is a controlled clinical trial of Vitamin D, K2, Magnesium and Zinc in 17 patients in people with rheumatoid arthritis.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2017 (Journal of oral science), a journal based in Japan.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Rheumatoid arthritis research.