Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham-controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The aim was to investigate whether continuous positive airway pressure treatment could modulate serum vitamin D (25-hydroxyvitamin D) and bone turnover markers (collagen-type 1 cross-linked C-telopeptide, osteocalcin and N-terminal propeptide of type 1 collagen) in secondary analysis from a randomized controlled trial.

Why It Was Studied

At 12 weeks, all participants received real continuous positive airway pressure for an additional 12 weeks.

There were no further differences in subgroup analyses (continuous positive airway pressure-compliant patients, patients with severe obstructive sleep apnea or sleepy patients).

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, men only.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

What Was Measured

The subject headings attached to it are Body Mass Index, Bone Remodeling, Continuous Positive Airway Pressure, Patient Compliance, Sleep Apnea, Obstructive and Vitamin D.

Author keywords: bone turnover markers, continuous positive airway pressure therapy, obstructive sleep apnea and randomized controlled trial.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2018 (Journal of sleep research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.