Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study.

Plain-language guide to PMID 28965564 (2017): clinical trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement), psoriasis and psoriatic arthritis.

Key Facts

PMID: 28965564
Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Year: 2017
Study type: Clinical Trial
Authors: Wacewicz M et al. (7 authors)
DOI: 10.1016/j.jtemb.2017.06.008

What This Study Did, in Plain Language

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in the context of psoriasis and psoriatic arthritis.

The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) and c-reactive protein (CRP) in the serum of patients with psoriasis.

Why It Was Studied

Psoriasis is a common, an inflammatory skin disease.

Trace elements may play an active role in the pathogenesis of psoriasis.

Who Took Part

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

In this case-control study sixty patients with psoriasis and fifty-eight healthy people were examined.

How the Study Was Run

Serum levels of Se, Zn and Cu were determined by atomic absorption spectrometry.

CRP was analyzed by immunoturbidimetric method.

Clinical activity of psoriasis was evaluated using Psoriasis Area and Severity Index (PASI).

What Was Measured

The subject headings attached to it are Antioxidants, C-Reactive Protein, Case-Control Studies, Copper, Psoriasis, Selenium and Ultraviolet Therapy.

The authors tagged it with the keywords Total antioxidant status and Zinc.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in people with psoriasis and psoriatic arthritis.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2017 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, Psoriasis and psoriatic arthritis research.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.