← Human Trials & Peer-Reviewed Studies
Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year.
Plain-language guide to PMID 28973683 (2017): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 28973683
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Martinaityte I et al. (5 authors)
- DOI
- 10.1210/jc.2017-01187
- Registered trial
- NCT01729013
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels after stopping vitamin D supplementation.
Why It Was Studied
Vitamin D and 25-hydroxyvitamin D [25(OH)D] are stored in adipose tissue, but the clinical relevance is uncertain.
Who Took Part
PubMed indexes the participants as middle-aged adults, older adults and people over 80, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
A prospective, double-blind cohort follow-up study.
Clinical Research Unit at University Hospital of North Norway.
During the 12-month follow-up period, blood samples were drawn at the beginning and after 1, 3, 6, 9, and 12 months.
Fat biopsies were taken at the start and end.
What Was Measured
Topics PubMed links to this paper include Adipose Tissue, Diabetes Mellitus, Type 2, Dietary Supplements, Vitamin D and Vitamin D Deficiency.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2017 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.