Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial.

Plain-language guide to PMID 29020329 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

Key Facts

PMID: 29020329
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year: 2018
Study type: Randomized Controlled Trial
Authors: Havens PL et al. (17 authors)
DOI: 10.1093/cid/cix753
Registered trial: NCT01751646

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

Who Took Part

PubMed indexes the participants as teenagers and young adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Outcome was change from baseline to week 48 in lumbar spine BMD (LSBMD).

Data presented are median (Q1, Q3).

What Was Measured

PubMed files the paper under topics including Anti-HIV Agents, Bone Density, Bone Density Conservation Agents, Calcium-Regulating Hormones and Agents, Cholecalciferol, HIV Infections and Spine.

Author keywords: bone mineral density, parathyroid hormone, tenofovir disoproxil fumarate and vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Parathyroid Hormone (PTH 1-84) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.