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Therapeutic effect of vitamin D in acute lower respiratory infection: A randomized controlled trial.
Plain-language guide to PMID 29072165 (2017): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 154 children.
Key Facts
- PMID
- 29072165
- Journal
- Clinical nutrition ESPEN
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Somnath SH et al. (5 authors)
- DOI
- 10.1016/j.clnesp.2017.02.003
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
To study the effect of vitamin D supplementation on the outcome of acute lower respiratory infection in hospitalized children.
Who Took Part
The abstract describes 154 children taking part.
By PubMed's age tags, the people studied were infants and young children, both men and women.
Serum 25(OH)D levels were measured at admission in all the children and 72 h after administration of vitamin D in the supplemented group.
How the Study Was Run
In design terms this was a randomized, open-label and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Everyone knew when Vitamin D, K2, Magnesium and Zinc was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
This is an open label parallel group randomized trial.
Primary outcome measured was the duration of hospital stay.
Primary outcome was compared using Mann Whitney U test and secondary outcomes were compared using chi-square or Fischer's exact test.
What Was Measured
The subject headings attached to it are Child, Hospitalized, Cholecalciferol, Dietary Supplements, Length of Stay and Respiratory Tract Infections.
Author keywords: Children, Lower respiratory infection (LRI)/Pneumonia and Vitamin D.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 154 children.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2017 (Clinical nutrition ESPEN), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.