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Oxytocin plasma levels predict the outcome of psychotherapy: A pilot study in chronic depression
Plain-language guide to PMID 29100154 (2018): pilot clinical trial study of Oxytocin.
Key Facts
- PMID
- 29100154
- Journal
- Journal of affective disorders
- Year
- 2018
- Study type
- Clinical Trial
- Authors
- Jobst A et al. (11 authors)
- DOI
- 10.1016/j.jad.2017.10.037
What This Study Did, in Plain Language
What Was Tested
Researchers studied Oxytocin in this clinical trial publication.
The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a specific form of psychotherapy for chronic depression, an illness in which interpersonal deficits play a major role.
In this pilot study, the researchers investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP.
Who Took Part
The age groups tagged for this paper are young adults, adults and middle-aged adults, both men and women.
Sixteen patients with chronic depression participated in a 10-week CBASP inpatient program.
Oxytocin plasma levels were measured before and after participants played a virtual ball-tossing game (Cyberball) that mimics social exclusion.
How the Study Was Run
The researchers set it up as a pilot study.
It is described as a pilot, a small early test of whether a larger Oxytocin study would be practical.
Clinical outcome after CBASP was evaluated with the Beck Depression Inventory-II (BDI-II) and the 24-item Hamilton Depression Rating Scale (HAMD-24).
What Was Measured
In this pilot study, the researchers investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP.
PubMed files the paper under topics including Chronic Disease, Cognitive Behavioral Therapy, Depression, Oxytocin, Pilot Projects, Psychiatric Status Rating Scales and Psychological Distance.
Author keywords: CBASP, Chronic depression, Cognitive behavioral analysis system of psychotherapy, Ostracism and Social exclusion.
What This Means in Plain Language
The paper is a pilot study of Oxytocin.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Journal of affective disorders), a journal based in Netherlands.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.