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Combining high-sensitivity cardiac troponin and B-type natriuretic peptide in the detection of inducible myocardial ischemia
Plain-language guide to PMID 29107010 (2018): clinical trial study of BNP (Nesiritide) in 1142 patients.
Key Facts
- PMID
- 29107010
- Journal
- Clinical biochemistry
- Year
- 2018
- Study type
- Clinical Trial
- Authors
- Puelacher C et al. (21 authors)
- DOI
- 10.1016/j.clinbiochem.2017.10.014
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of BNP (Nesiritide), published as a clinical trial.
Single biomarker approaches provide only moderate accuracy in the non-invasive detection of exercise-induced myocardial ischemia.
The researchers included 1142 consecutive patients with suspected inducible ischemia, and evaluated the added value of the biomarkers high-sensitivity cardiac troponin (hs-cTn) and B-type natriuretic peptide (BNP), alone and in combination, on top of clinical judgment.
Who Took Part
According to the abstract, 1142 patients were involved.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
Consecutive patients with suspected myocardial ischemia referred to stress myocardial perfusion single-photon emission tomography imaging (MPI) were enrolled.
Clinical judgment (CJ) of the treating cardiologist regarding myocardial ischemia, quantified using a visual analogue scale, and blood concentrations of hs-cTnI and BNP were determined before and after stress.
How the Study Was Run
The presence of myocardial ischemia was adjudicated by independent cardiologists using MPI, blinded to biomarker measurements.
What Was Measured
The researchers included 1142 consecutive patients with suspected inducible ischemia, and evaluated the added value of the biomarkers high-sensitivity cardiac troponin (hs-cTn) and B-type natriuretic peptide (BNP), alone and in combination, on top of clinical judgment.
The subject headings attached to it are Area Under Curve, Biomarkers, Coronary Artery Disease, Electrocardiography, Exercise, Exercise Test and Myocardial Infarction.
The authors tagged it with the keywords B-type natriuretic peptide, High-sensitivity cardiac troponin, Myocardial ischemia and Sensitivity and specificity.
What This Means in Plain Language
This is a clinical trial of BNP (Nesiritide) in 1142 patients.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2018 (Clinical biochemistry), a journal based in United States.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.