Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a phase 3 clinical trial.

Approximately half of women taking aromatase inhibitor (AI) therapy develop AI-induced arthralgia (AIA), and many might discontinue AI therapy because of the pain.

Who Took Part

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, women only.

Within an 893-participant nested case-control AIA genome-wide association study, the researchers nested a 72 AIA case-144 control assessment of vitamin D plasma concentrations, corrected for seasonal and geographic variation.

Finally, the researchers analyzed the multivariate effects of baseline factors: vitamin D level, previously identified musculoskeletal single nucleotide polymorphisms, age, body mass index, and vitamin D receptor (VDR) Fok-I variant genotype on AIA development.

How the Study Was Run

MA.27 is a phase III adjuvant trial comparing 2 AIs, exemestane versus anastrozole.

The researchers also examined 9 baseline inflammatory cytokines: interleukin (IL)-1β, IL-6, tumor necrosis factor-α, interferon (IFN)γ, IL-10, IL-12p70, IL-17, IL-23, and chemokine ligand (CCL)-20.

What Was Measured

Topics PubMed links to this paper include Anastrozole, Androstadienes, Aromatase Inhibitors, Arthralgia, Breast Neoplasms, Case-Control Studies and Chemotherapy, Adjuvant.

The authors tagged it with the keywords Aromatase inhibitor-induced arthralgias, IL-1 beta, Inflammatory cytokines, Vitamin D and Vitamin D receptor polymorphisms.

What This Means in Plain Language

This is a phase 3 clinical trial of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Clinical breast cancer), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.