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CGRP and PTX3 as Predictors of Efficacy of Onabotulinumtoxin Type A in Chronic Migraine: An Observational Study
Plain-language guide to PMID 29131327 (2018): observational study of CGRP (Calcitonin Gene-Related Peptide), migraine.
Key Facts
- PMID
- 29131327
- Journal
- Headache
- Year
- 2018
- Study type
- Observational Study
- Authors
- Domínguez C et al. (10 authors)
- DOI
- 10.1111/head.13211
What This Study Did, in Plain Language
What Was Tested
Researchers studied CGRP (Calcitonin Gene-Related Peptide) in the context of migraine in this observational study publication.
The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA).
Why It Was Studied
Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome.
Who Took Part
The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.
The researchers measured serum levels of biomarkers of inflammation (IL-6, IL-10, TNF-α, and hs-CRP), endothelial dysfunction (PTX3 and sTWEAK), blood-brain barrier disruption (cFN), brain damage (S100b, NSE), and trigemino-vascular activation (CGRP) by ELISA in a group of CM patients treated with OnabotA and healthy controls.
How the Study Was Run
The researchers compared baseline levels of biomarkers between these groups.
What Was Measured
Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome.
PubMed files the paper under topics including Botulinum Toxins, Type A, C-Reactive Protein, Calcitonin Gene-Related Peptide, Chronic Disease, Cytokines, Migraine Disorders and Neuromuscular Agents.
Author keywords: CGRP, PTX3, chronic migraine, onabotulinumtoxin A, outcome and predictors.
What This Means in Plain Language
This is an observational study of CGRP (Calcitonin Gene-Related Peptide) in people with migraine.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Headache), a journal based in United States.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.