Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.

The goal of their study was to evaluate the prevalence of hypovitaminosis D and its determinants as well as PTH serum level determinants and associations of the 25-hydroxyvitamin D and PTH serum levels with MetS and its individual components in a sample of the Portuguese mainland population.

Why It Was Studied

Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis.

Estimates of the VitD status in several European countries show large variations between them.

Who Took Part

The abstract describes 4095 adults taking part.

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

PORMETS is a national cross-sectional study that includes a total sample of 4095 adults.

A subsample, including 500 participants, was randomly selected for the present study.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A structured questionnaire was administered to collect information on personal medical histories and socio-demographic and behavioral characteristics.

Blood pressure and anthropometrics measurements were performed.

Fasting venous samples were collected and PTH and 25-hydroxyvitamin D were measured.

VitD adequacy was classified according to the Institute of Medicine, and MetS was classified according to the Joint Interim Statement recommendations.

Multiple linear regression and unconditional logistic regression models were used to estimate the associations between the levels of PTH and 25-hydroxyvitamin D and with MetS and its individual components.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Body Mass Index, Cross-Sectional Studies, Metabolic Syndrome, Parathyroid Hormone, Portugal and Prevalence.

The authors tagged it with the keywords Cardiovascular risk, Functional hypoparathyroidism, PTH and Vitamin D.

What This Means in Plain Language

The paper is a randomized study of Parathyroid Hormone (PTH 1-84) in 4095 adults.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (BMC endocrine disorders), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.