The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.

Who Took Part

PubMed indexes the participants as middle-aged adults, women only.

The researchers carried out a prospective study in postmenopausal women randomized to calcium and vitamin D supplementation or calcium, vitamin D, and genistein supplementation.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Vitamin D, parathyroid hormone (PTH), cross-linked C-telopeptide (CTX), and procollagen 1 N-terminal (P1NP) were determined by electrochemiluminescence.

Three SNPs - rs2231142 (ABCG2), rs358231 (cytosolic β-glucosidase [CBG]), and rs2273697 (ABCC2) - were determined.

What Was Measured

Topics PubMed links to this paper include ATP Binding Cassette Transporter, Subfamily G, Member 2, Biomarkers, Bone Remodeling, Calcium, Dietary, Collagen Type I, Dietary Supplements and Genistein.

The authors tagged it with the keywords Cross-linked C-telopeptide, Parathyroid hormone, Polymorphism, Procollagen 1 N-terminal and Vitamin D.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (Journal of nutrigenetics and nutrigenomics), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Parathyroid Hormone (PTH 1-84) compound page, all human trials.