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Vitamin D deficiency in critically ill children: a systematic review and meta-analysis.
Plain-language guide to PMID 29169388 (2017): meta-analysis of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 29169388
- Journal
- Critical care (London, England)
- Year
- 2017
- Study type
- Meta-Analysis
- Authors
- McNally JD et al. (9 authors)
- DOI
- 10.1186/s13054-017-1875-y
What This Paper Covers, in Plain Language
What It Covers
Researchers studied Vitamin D, K2, Magnesium and Zinc in this meta-analysis publication.
The objective of this systematic review was to determine the frequency of VDD in pediatric critical illness and its association with clinical outcomes.
The primary objective was to estimate the prevalence of VDD in the pediatric intensive care unit (PICU) and compare vitamin D status with healthy control populations.
Why It Was Studied
Vitamin D deficiency (VDD) has been hypothesized not only to be common but also to represent a potentially modifiable risk factor for greater illness severity and clinical outcome during critical illness.
Registered on 11 January 2016.
Who the Included Studies Covered
By PubMed's age tags, the people studied were infants, young children, children and teenagers.
Random effects meta-analysis was used to calculate pooled VDD event rate, compare levels with those of control subjects, and evaluate for associations between VDD and clinical outcome.
How the Review Was Done
MEDLINE, Embase, and CENTRAL were searched through December 12, 2016, with no date or language restrictions.
What Was Measured
Vitamin D deficiency (VDD) has been hypothesized not only to be common but also to represent a potentially modifiable risk factor for greater illness severity and clinical outcome during critical illness.
Topics PubMed links to this paper include Critical Illness, Intensive Care Units, Pediatric, Patient Outcome Assessment, Risk Factors and Vitamin D Deficiency.
Author keywords: Meta-analyses, Mortality, Nutrition, Pediatrics and Systematic review.
What This Means in Plain Language
This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2017 (Critical care (London, England)), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.