High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals

What Was Tested

This randomized controlled trial paper looks at Apelin in the context of low blood pressure and orthostatic hypotension.

Their purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals.

Why It Was Studied

Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide.

Apelin levels and NO bioavailability are impaired in older hypertensive patients.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Apelin and who got the comparison, which limits bias.

What Was Measured

Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide.

Apelin levels and NO bioavailability are impaired in older hypertensive patients.

The subject headings attached to it are Aging, Antihypertensive Agents, Apelin, Biomarkers, Blood Pressure, Combined Modality Therapy and Heart Rate.

The authors tagged it with the keywords Endothelin-1, High-intensity interval training, NOx and Older treated hypertensive.

What This Means in Plain Language

The paper is a randomized study of Apelin in people with low blood pressure and orthostatic hypotension.

The publication is from 2018 (Journal of physiology and biochemistry), a journal based in Spain.

More context: the Apelin compound page, Low blood pressure and orthostatic hypotension research.