← Human Trials & Peer-Reviewed Studies
Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial.
Plain-language guide to PMID 29256407 (2017): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 18 individuals.
Key Facts
- PMID
- 29256407
- Journal
- Magnesium research
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Rodríguez-Ramírez M et al. (4 authors)
- DOI
- 10.1684/mrh.2017.0426
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
A stringent regulation of influx and efflux of magnesium by cation transporters seems to play an important role in the regulation of blood pressure (BP).
With this regard, the researchers evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN).
Who Took Part
The study group was 18 individuals.
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the individuals nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some individuals received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
With this regard, the researchers evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN).
The subject headings attached to it are Blood Pressure, Cation Transport Proteins, Magnesium, Prehypertension, Protein Serine-Threonine Kinases and TRPM Cation Channels.
The authors tagged it with the keywords SLC41A1, TRPM6, TRPM7 and pre-hypertension.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 18 individuals.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2017 (Magnesium research), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.