A Randomized in situ Clinical Study of Fluoride Dentifrices on Enamel Remineralization and Resistance to Demineralization: Effects of Zinc.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

This study aimed to determine the effect of zinc ions and F concentration in a dentifrice on remineralization of early caries lesions in situ and on resistance to subsequent demineralization.

Why It Was Studied

This was a single-center, 6-period, 6-product, blinded (examiner, subject, analyst), randomized (n = 62), crossover study.

Subjects wore palatal appliances holding partially demineralized bovine enamel specimens.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, single-blind and crossover study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In this single-blind Vitamin D, K2, Magnesium and Zinc study one party knew the assignments and the other did not.

In the crossover set-up each of the participants took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

What Was Measured

Surface microhardness (SMH), measured pre-experimental, post-initial acid exposure, post-remineralization, and post-second acid exposure, was used to calculate recovery (SMHR), net acid resistance (NAR), and a new, specifically demineralization-focused calculation, "comparative acid resistance" (CAR).

Enamel fluoride uptake (EFU) was also measured.

Topics PubMed links to this paper include Dentifrices, Fluorides, Tooth Demineralization, Tooth Remineralization and Zinc.

Author keywords: Enamel caries, Tooth brushing, Toothpastes and Topical fluorides.

What This Means in Plain Language

The paper is a randomized, single-blind and crossover study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2018 (Caries research), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.