Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The purpose of this study was to establish the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk of GDM patients.

Why It Was Studied

To the best their knowledge, data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk in gestational diabetes mellitus (GDM) are scarce.

Fasting blood samples were taken at baseline and week 6 to quantify related markers.

Who Took Part

The abstract describes 6 patients taking part.

The age groups tagged for this paper are teenagers, young adults and adults, women only.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

PubMed files the paper under topics including Biomarkers, Blood Glucose, Calcium, Diabetes, Gestational, Dietary Supplements, Insulin and Insulin Resistance.

Author keywords: cardiometabolic risk, contrôle glycémique, diabète gestationnel, gestational diabetes mellitus, glycemic control and risque cardiométabolique.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 6 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2018 (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme), a journal based in Canada.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.