A randomized controlled trial comparing the myocardial protective effects of isoflurane with propofol in patients undergoing elective coronary artery bypass surgery on cardiopulmonary bypass, assessed by changes in N-terminal brain natriuretic peptide

What Was Tested

Researchers studied BNP (Nesiritide) in this randomized controlled trial publication.

The objective of the study is to compare the myocardial protective effects of isoflurane with propofol in patients undergoing elective coronary artery bypass surgery on cardiopulmonary bypass (CPB), the cardio protection been assessed by changes in N-terminal brain natriuretic peptide (NT proBNP).

Methodology and Design: This study is designed as a participant blinded, prospective randomized clinical trial.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

Patients undergoing elective coronary artery bypass surgery on CPB.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Christian Medical College Hospital, Vellore, India.

Anesthesia was maintained with 0.8-1.2 end tidal concentrations of isoflurane in the isoflurane group and in the propofol group, anesthesia was maintained with propofol infusion as described by Roberts et al.

Hemodynamic data were recorded at frequent intervals during the surgery and up to 24 h in the Intensive Care Unit (ICU).

What Was Measured

Topics PubMed links to this paper include Cardiopulmonary Bypass, Cardiotonic Agents, Creatine Kinase, MB Form, Elective Surgical Procedures, Hemodynamics, Isoflurane and Natriuretic Peptide, Brain.

What This Means in Plain Language

The paper is a randomized study of BNP (Nesiritide).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Annals of cardiac anaesthesia), a journal based in India.

More context: the BNP (Nesiritide) compound page, all human trials.