Vitamin D deficiency and its relationship with cardiac iron and function in patients with transfusion-dependent thalassemia at Chiang Mai University Hospital.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this clinical trial publication.

To determine the prevalence of Vitamin D deficiency and to explore the impact of Vitamin D deficiency on cardiac iron and function in patients with transfusion-dependent thalassemia.

Why It Was Studied

Vitamin D deficiency is common in patients with thalassemia.

Vitamin D deficiency could be related to cardiac dysfunction.

Who Took Part

By PubMed's age tags, the people studied were children, teenagers and adults, both men and women.

A cross-sectional study in patients with Transfusion-dependent thalassemia was conducted.

Patients with liver disease, renal disease, type 1 diabetes, malabsorption, hypercortisolism, malignancy, and contraindication for MRI were excluded.

How the Study Was Run

Calcium, phosphate, PTH, vitamin D-25OH were measured.

CardiacT2* and liver iron concentration (LIC) and left ventricular ejection fraction (LVEF) were determined.

Results Sixty-one (33M/28F) patients with Transfusion-dependent thalassemia were enrolled.

Serum calcium, phosphate, PTH, LIC, cardiac T2*, and LVEF were not different between the groups with or without Vitamin D deficiency.

What Was Measured

PubMed files the paper under topics including Blood Transfusion, Cross-Sectional Studies, Heart Diseases, Iron, Myocardium, Prevalence and Thalassemia.

The authors tagged it with the keywords Cardiac iron, Vitamin D, cardiac function and transfusion-dependent thalassemia.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Pediatric hematology and oncology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.