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Dose-Response Effects of Early Vitamin D Supplementation on Neurodevelopmental and Respiratory Outcomes of Extremely Preterm Infants at 2 Years of Age: A Randomized Trial.
Plain-language guide to PMID 29393233 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 29393233
- Journal
- Neonatology
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Salas AA et al. (6 authors)
- DOI
- 10.1159/000484399
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Many extremely preterm infants have low vitamin D concentrations at birth, but early childhood outcomes after vitamin D supplementation have not been reported.
Who Took Part
By PubMed's age tags, the people studied were infants and young children, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
The primary outcome of this follow-up study was Bayley III cognitive score at 22-26 months of age.
What Was Measured
Many extremely preterm infants have low vitamin D concentrations at birth, but early childhood outcomes after vitamin D supplementation have not been reported.
Topics PubMed links to this paper include Cognition, Dietary Supplements, Gestational Age, Infant, Extremely Premature, Infant, Premature, Diseases, Neuropsychological Tests and Vitamin D.
Author keywords: Neurocognitive outcomes, Neurodevelopment, Nutritional requirements, Premature Infants and Respiratory outcomes.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Neonatology), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.