← Human Trials & Peer-Reviewed Studies
Zinc supplementation does not influence serum levels of VEGF, BDNF, and NGF in diabetic retinopathy patients: a randomized controlled clinical trial.
Plain-language guide to PMID 29421993 (2019): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 50 patients, diabetic retinopathy and glaucoma.
Key Facts
- PMID
- 29421993
- Journal
- Nutritional neuroscience
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Kheirouri S et al. (3 authors)
- DOI
- 10.1080/1028415X.2018.1436236
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of diabetic retinopathy and glaucoma in this randomized controlled trial publication.
Objectives: This study was aimed to evaluate the effects of zinc (Zn) supplementation on serum levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with diabetic retinopathy (DR).
Why It Was Studied
Results: Forty-five patients completed the intervention.
Levels of VEGF, BDNF and NGF were not affected by the Zn supplementation.
Who Took Part
The abstract describes 50 patients taking part.
The age groups tagged for this paper are middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Metabolic parameters and blood pressure were measured.
Serum levels of Zn were assessed by atomic absorption spectrophotometry and serum levels of VEGF, BDNF and NGF by ELISA.
What Was Measured
Levels of VEGF, BDNF and NGF were not affected by the Zn supplementation.
Topics PubMed links to this paper include Brain-Derived Neurotrophic Factor, Diabetic Retinopathy, Nerve Growth Factor, Vascular Endothelial Growth Factor A and Zinc.
Author keywords: BDNF, NGF and VEGF.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 50 patients in people with diabetic retinopathy and glaucoma.
The publication is from 2019 (Nutritional neuroscience), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Diabetic retinopathy and glaucoma research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.