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The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.
Plain-language guide to PMID 29432877 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 60 people.
Key Facts
- PMID
- 29432877
- Journal
- Progress in neuro-psychopharmacology & biological psychiatry
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Raygan F et al. (4 authors)
- DOI
- 10.1016/j.pnpbp.2018.02.007
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
This study was carried out to evaluate the effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in diabetic people with coronary heart disease (CHD).
Who Took Part
The study group was 60 people.
The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The people were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the people nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some people received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
This randomized, double-blind, placebo-controlled trial was carried out among 60 diabetic people with CHD, aged 45-85 years old.
What Was Measured
The subject headings attached to it are Anxiety, Coronary Disease, Depression, Diabetes Mellitus, Type 2, Dietary Supplements, Metabolome and Probiotics.
The authors tagged it with the keywords Coronary heart disease, Inflammation, Mental health, Oxidative stress, Type 2 diabetes mellitus and Vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 60 people.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Progress in neuro-psychopharmacology & biological psychiatry), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.