Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The researchers investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD).

Who Took Part

According to the abstract, 20 children were involved.

The age groups tagged for this paper are children and teenagers, both men and women.

In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the children and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Age- and gender-related standard deviation scores (SDSs) were calculated.

What Was Measured

The researchers investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD).

The subject headings attached to it are Alkaline Phosphatase, Biomarkers, Bone Density, Dietary Supplements, Fibroblast Growth Factor-23, Fibroblast Growth Factors and Glomerular Filtration Rate.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 20 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.