Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of chronic and systemic inflammation, published as a meta-analysis.

The aim of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on inflammatory markers in patients with type 2 diabetes and to identify relevant gaps in knowledge.

Why It Was Studied

Vitamin D has been proposed to have anti-inflammatory properties; however, the effect of vitamin D supplementation on inflammation in type 2 diabetes has not been established.

MEDLINE, CINAHL, Embase, and EBM Reviews were searched systematically from inception to January 25, 2017.

Who the Included Studies Covered

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Study and sample characteristics and aggregate outcome data were extracted, risk of bias was determined, and quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.

What Was Measured

Topics PubMed links to this paper include Adipokines, Anti-Inflammatory Agents, Biomarkers, C-Reactive Protein, Cytokines, Diabetes Mellitus, Type 2 and Dietary Supplements.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with chronic and systemic inflammation.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Nutrition reviews), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Chronic and systemic inflammation research.