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Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial.
Plain-language guide to PMID 29499976 (2019): double-blind randomized controlled trial of Cyanocobalamin (Vitamin B12).
Key Facts
- PMID
- 29499976
- Journal
- Clinical nutrition (Edinburgh, Scotland)
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Del Bo' C et al. (6 authors)
- DOI
- 10.1016/j.clnu.2018.02.008
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.
Vegetarians and vegans are more vulnerable to vitamin B12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression.
Who Took Part
PubMed indexes the participants as adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and parallel-group study.
Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.
Groups ran in parallel: each of the participants stayed in one arm throughout.
A 12-week randomized, double-blind, controlled, parallel intervention trial was performed.
Blood samples were collected at baseline and after 15, 30, 60, and 90 days from the intervention for the determination of vitamin B12, related metabolic markers, and blood cell counts.
What Was Measured
The subject headings attached to it are Administration, Sublingual, Nutritional Status, Vegans, Vegetarians, Vitamin B 12, Vitamin B 12 Deficiency and Vitamins.
The authors tagged it with the keywords Metabolites, Sublingual supplements and Vitamin B(12).
What This Means in Plain Language
The paper is a randomized, double-blind and parallel-group study of Cyanocobalamin (Vitamin B12).
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2019 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.