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Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review.
Plain-language guide to PMID 29501516 (2018): systematic review of ACTH (Corticotropin) and Cosyntropin.
Key Facts
- PMID
- 29501516
- Journal
- World neurosurgery
- Year
- 2018
- Study type
- Systematic Review
- Authors
- Roca E et al. (9 authors)
- DOI
- 10.1016/j.wneu.2018.02.120
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of ACTH (Corticotropin) and Cosyntropin, published as a systematic review.
The most frequent hormonal associations are with prolactin and growth hormone (GH).
Here the researchers describe a rare case of functional adrenocorticotropic hormone (ACTH) and GH microadenoma and report their findings from a systematic literature review of PHA.
Who the Included Studies Covered
PubMed indexes the participants as middle-aged adults, women only.
Because of clinical and biochemical evidence of acromegaly, surgery was recommended.
Postoperatively, hormonal replacement therapy was started because of adrenal insufficiency.
How the Review Was Done
The researchers searched PubMed using the terms "plurihormonal pituitary adenoma," "ACTH GH pituitary adenoma," and "acromegaly AND Cushing's disease".
Histologically, 19 were pituitary adenomas composed of two distinct cell populations, while only in 1 case was there evidence of a single cell producing both ACTH and GH.
In the case reported here, a 60-year-old woman was incidentally diagnosed with a pituitary microadenoma.
Her antihypertensive therapy was discontinued due to evidence of normal blood pressure values.
Histological examination revealed an ACTH-GH PHA with 2 distinct populations of secreting cells.
What Was Measured
PubMed files the paper under topics including Adenoma, Adrenocorticotropic Hormone, Antineoplastic Agents, Hormonal, Growth Hormone, Pituitary Neoplasms and Prolactin.
The authors tagged it with the keywords ACTH, Acromegaly, Cushing, GH, Plurihormonal pituitary adenoma and Transsphenoidal surgery.
What This Means in Plain Language
This is a systematic review of ACTH (Corticotropin) and Cosyntropin.
Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2018 (World neurosurgery), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the Cosyntropin compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
Cosyntropin: A synthetic 24-amino-acid fragment of ACTH (also tetracosactide, Synacthen) used mainly in the adrenal stimulation test.
Alpha-MSH: A 13-amino-acid hormone that drives skin pigmentation and calms inflammation; afamelanotide (Melanotan I) is an analog.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.