Subclinical impairment of myocardial and endothelial functionality in very early psoriatic and rheumatoid arthritis patients: Association with vitamin D and inflammation.

Plain-language guide to PMID 29524864 (2018): observational study of Vitamin D, K2, Magnesium and Zinc, psoriasis and psoriatic arthritis.

Key Facts

PMID: 29524864
Journal: Atherosclerosis
Year: 2018
Study type: Observational Study
Authors: Lo Gullo A et al. (10 authors)
DOI: 10.1016/j.atherosclerosis.2018.03.004

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of psoriasis and psoriatic arthritis and rheumatoid arthritis in this observational study publication.

The aim of this study was to evaluate the myocardial functionality by speckle-tracking echocardiography (STE) in recent onset RA and PsA patients and its potential associations with the levels of circulating CD34 + cells, vitamin D, and with disease activity.

STE was used to assess the myocardial functionality in patients with very early RA (n = 41) and PsA (n = 35) without traditional CV risk factors, and 58 matched healthy controls (HC).

Who Took Part

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

Global longitudinal and circumferential strain (GLS and GCS) was estimated.

Pulse wave velocity (PWV) and carotid intima-media thickness (cIMT) were measured as surrogate markers of atherosclerosis.

Circulating CD34 + counts were evaluated by flow cytometry and vitamin D levels were quantified by HPLC.

Disease activity was assessed by Disease Activity Score-28 (DAS28).

What Was Measured

The subject headings attached to it are Antigens, CD34, Arthritis, Psoriatic, Arthritis, Rheumatoid, Asymptomatic Diseases, Biomarkers, Cardiovascular Diseases and Carotid Intima-Media Thickness.

The authors tagged it with the keywords Inflammatory joint diseases, Rheumatoid arthritis, Speckle-tracking echocardiography and Vitamin D.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in people with psoriasis and psoriatic arthritis.

Results are reported in around 10 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Atherosclerosis), a journal based in Ireland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Psoriasis and psoriatic arthritis research, Rheumatoid arthritis research.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.