The Effect of Vitamin D Supplementation on Breast Density Changes: A Clinical Trial Study.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Who Took Part

The abstract describes 400 women taking part.

PubMed indexes the participants as adults and middle-aged adults, women only.

This double-blind, placebo-controlled, single center clinical trial was conducted among 400 women aged 40 yr and older.

Participants were allocated to 2 groups.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Participants had follow-up clinic visits every 6 mo and received an annual mammogram.

What Was Measured

Topics PubMed links to this paper include Breast Density, Cholecalciferol, Dietary Supplements, Iran and Logistic Models.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 400 women.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Nutrition and cancer), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.