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Do independent geriatric outpatients with nocturnal polyuria profit from desmopressin?
Plain-language guide to PMID 29541862 (2019): double-blind randomized controlled trial study of Vasopressin and Desmopressin in 55 patients.
Key Facts
- PMID
- 29541862
- Journal
- Zeitschrift fur Gerontologie und Geriatrie
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Weinrebe W et al. (6 authors)
- DOI
- 10.1007/s00391-018-1379-7
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vasopressin and Desmopressin in this randomized controlled trial publication.
Who Took Part
According to the abstract, 55 patients were involved.
PubMed indexes the participants as older adults, women only.
On days 2, 5 and 10 creatinine, blood urea nitrogen (bun), blood count and C‑reactive protein (CrP), vena cava diameter and bioimpedance were measured and a structured interview was implemented (voiding frequency, sleeping behavior and subjective and cognitive behavior).
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.
Neither the patients nor the staff measuring them knew who was on Vasopressin, so expectations could not easily colour the readings.
Some patients received a placebo instead of Vasopressin, giving a reference point.
The Vasopressin group and the comparison group ran side by side rather than switching.
On day 1 voiding frequency, voiding volumes day and night, serum osmolarity and arginine-vasopressin (AVP) were measured at 7 p.m.
What Was Measured
Topics PubMed links to this paper include Deamino Arginine Vasopressin, Nocturia, Outpatients and Polyuria.
The authors tagged it with the keywords AVP, Desmopressin, Independent geriatric outpatients and Nocturnal polyuria.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 55 patients.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2019 (Zeitschrift fur Gerontologie und Geriatrie), a journal based in Germany.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.