Effect of hypotensive therapy combined with modified diet or zinc supplementation on biochemical parameters and mineral status in hypertensive patients.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

To evaluate the effect of a hypotensive treatment, modified diet and zinc supplementation on mineral status and selected biochemical parameters in newly diagnosed hypertensive patients on monotherapy.

Why It Was Studied

Hypotensive therapy leads to a number of trace elements metabolism disturbances.

Zinc balance is frequently affected by antihypertensive treatment.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

In the first stage, arterial hypertension in ninety-eight human subjects was diagnosed.

In the second stage, antihypertensive monopharmacotherapy was implemented.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

In the third stage, patients were randomized into three groups and continued antihypertensive monotherapy: group D received an optimal-mineral-content diet, group S received zinc supplementation, and group C had no changes in diet or zinc supplementation.

Iron, zinc, and copper concentrations in serum, erythrocytes, urine, and hair were determined.

Lipids, glucose, ceruloplasmin, ferritin, albumin, C-reactive protein (CRP), tumor necrosis factor α (TNF-α), nitric oxide (NO), superoxide dismutase (SOD) and catalase (CAT) were assayed in serum.

What Was Measured

The subject headings attached to it are Antihypertensive Agents, Catalase, Dietary Supplements, Hypertension, Minerals, Superoxide Dismutase and Tumor Necrosis Factor-alpha.

The authors tagged it with the keywords Antihypertensive monotherapy, Mineral status, Zinc and Zinc supplementation.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.