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SERUM FREE CORTISOL DURING GLUCAGON STIMULATION TEST IN HEALTHY SHORT-STATURED CHILDREN AND ADOLESCENTS
Plain-language guide to PMID 29547045 (2018): clinical trial study of Glucagon.
Key Facts
- PMID
- 29547045
- Journal
- Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
- Year
- 2018
- Study type
- Clinical Trial
- Authors
- Weintrob N et al. (6 authors)
- DOI
- 10.4158/EP-2017-0132
What This Study Did, in Plain Language
What Was Tested
Researchers studied Glucagon in this clinical trial publication.
The total cortisol (TC) response may be measured during the glucagon stimulation test (GST) for growth hormone (GH) reserve in order to assess the integrity of the hypothalamic-pituitary-adrenal (HPA) axis.
Measurements of TC are unreliable in conditions of albumin and cortisol-binding globulin (CBG) alterations (e.g., hypoproteinemia or CBG deficiency).
The researchers aimed to measure the serum free cortisol (sFC) response to the GST in children and adolescents and determine whether it could predict the GH response to glucagon stimulation.
Why It Was Studied
ACTH = adrenocorticotrophic hormone BMI = body mass index CBG = cortisol-binding globulin GH = growth hormone GST = glucagon stimulation test HPA = hypothalamic-pituitary-adrenal SDS = standard deviation score sFC = serum free cortisol TC = total cortisol.
Who Took Part
By PubMed's age tags, the people studied were infants, young children, children and teenagers, both men and women.
Infants and children with either short stature or growth attenuation who were referred for evaluation of GH reserve underwent the GST.
What Was Measured
ACTH = adrenocorticotrophic hormone BMI = body mass index CBG = cortisol-binding globulin GH = growth hormone GST = glucagon stimulation test HPA = hypothalamic-pituitary-adrenal SDS = standard deviation score sFC = serum free cortisol TC = total cortisol.
Topics PubMed links to this paper include Adrenocorticotropic Hormone, Body Height, Glucagon, Growth Disorders, Health, Human Growth Hormone and Hydrocortisone.
What This Means in Plain Language
This is a clinical trial of Glucagon.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2018 (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists), a journal based in United States.
More context: the Glucagon compound page, all human trials.
Our Notes on the Compound
Glucagon: A 29-amino-acid pancreatic hormone that raises blood glucose; used as a rescue medicine for severe low blood sugar and as a diagnostic aid.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.