Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia - Randomized controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Vitamin D plays pivotal role in decidualization and implantation of the placenta.

Who Took Part

The study group was 179 women.

The age groups tagged for this paper are young adults and adults, women only.

An open labelled randomized controlled study was conducted on 179 pregnant women presenting in King Fahad Medical City antenatal clinic from Oct 2012-Oct 2015.

Patients with age less than 20 years or more than 40 years, pregnancy with fetal anomalies, history of hypertension, pre-eclampsia, recurrent miscarriage, chronic renal or hepatic disease and malignancy were excluded from the study.

How the Study Was Run

In design terms this was a randomized and open-label study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Being open-label, the Vitamin D, K2, Magnesium and Zinc study did not mask who received what.

Serum 25[OH]D was analysed during the first trimester (between 6 and 12 weeks of pregnancy).

What Was Measured

PubMed files the paper under topics including Cholecalciferol, Dietary Supplements, Pre-Eclampsia, Risk and Vitamins.

Author keywords: Deficiency, IUGR, Insufficiency, Preeclampsia, Pregnancy and Vitamin D.

What This Means in Plain Language

The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc in 179 women.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.