Effect of oral vitamin D supplementation on glycemic control in patients with type 2 diabetes mellitus with coexisting hypovitaminosis D: A parellel group placebo controlled randomized controlled pilot study.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

To investigate effect of oral vitamin D supplementation on glycemic control, in patients with type 2 diabetes mellitus and coexisting hypovitaminosis D.

Repeated measures ANOVA was undertaken to compare values over time.

Why It Was Studied

Intra-group comparison was made by paired t test & unpaired t test was used for inter-group (A v/s B) comparisons.

Who Took Part

The study group was 2 patients.

PubMed indexes the participants as middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, placebo-controlled, parallel-group and pilot.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Groups ran in parallel: each of the patients stayed in one arm throughout.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

Randomized, Parallel Group, Placebo Controlled Trial carried out in a tertiary care hospital of Indian Armed Forces.

What Was Measured

Intra-group comparison was made by paired t test & unpaired t test was used for inter-group (A v/s B) comparisons.

PubMed files the paper under topics including Biomarkers, Blood Glucose, Case-Control Studies, Diabetes Mellitus, Type 2, Dietary Supplements, Glycated Hemoglobin and Glycemic Index.

The authors tagged it with the keywords Glycemic control, Hypovitaminosis D, Type 2 diabetes mellitus and Vitamin D.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 2 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Diabetes & metabolic syndrome), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.