Effect of vitamin D and omega-3 on nocturnal enuresis of 7-15-year-old children.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This was a 2-month randomized, placebo-controlled, double-blind trial to measure the effects of vitamin D, omega-3 supplements, and their combination on nocturnal enuresis among 7-15-year-old children.

Why It Was Studied

Nocturnal enuresis is known to be a common urinary bladder complication in children.

Recent studies have associated vitamin D and omega-3 insufficiency with nocturnal enuresis.

Who Took Part

The abstract describes 180 children taking part.

By PubMed's age tags, the people studied were children and teenagers, both men and women.

Participants (180 children with nocturnal enuresis) were selected from children referred to the Pediatric ward of Imam Reza Clinic in Shiraz, Iran.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The children were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the children and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Demographic information and anthropometric measures were taken.

Fasting blood and urine samples were also collected, and serum vitamin D and urine prostaglandin E2 were measured before and after intervention.

What Was Measured

PubMed files the paper under topics including Fatty Acids, Omega-6, Nocturnal Enuresis, Urinary Bladder, Urination, Vitamin D and Vitamins.

Author keywords: Omega-3 fatty acids and Prostaglandin E2.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 180 children.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Journal of pediatric urology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.