Effects of vitamin D supplementation on FGF23: a randomized-controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Fibroblast growth factor-23 (FGF23) is critical for phosphate homeostasis.

Considering the high prevalence of vitamin D deficiency and the association of FGF23 with adverse outcomes, the researchers investigated effects of vitamin D3 supplementation on FGF23 concentrations.

Who Took Part

The age groups tagged for this paper are middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

This is a post-hoc analysis of the Styrian Vitamin D Hypertension trial, a single-center, double-blind, randomized, placebo-controlled trial, conducted from 2011 to 2014 at the Medical University of Graz, Austria.

Primary outcome was the between-group difference in FGF23 levels at study end while adjusting for baseline values.

What Was Measured

Topics PubMed links to this paper include Austria, Cholecalciferol, Cohort Studies, Dietary Supplements, Fibroblast Growth Factor-23 and Fibroblast Growth Factors.

The authors tagged it with the keywords Calcitriol, FGF23, Phosphate, RCT and Vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.