Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Who Took Part

The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults, older adults and people over 80, both men and women.

This was a single-centre, randomised, blinded (examiner/laboratory analyst), six-treatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture.

Human enamel specimens containing early-stage, surface-softened (A-lesions) or more advanced, subsurface (B-lesions) caries lesions were placed into the buccal flanges of participants' modified partial denture (one of each lesion type per side).

How the Study Was Run

In design terms this was a randomized, placebo-controlled and crossover study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

In the crossover set-up each of the participants took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

A-lesions were analysed for surface microhardness recovery.

Both lesion types were analysed by transverse microradiography and for enamel fluoride uptake, with B-lesions additionally analysed by quantitative light-induced fluorescence.

Comparison was carried out using an analysis of covariance model.

What Was Measured

The subject headings attached to it are Cariostatic Agents, Dental Caries, Dental Enamel, Fluorides, Indiana, Microradiography and Phytic Acid.

The authors tagged it with the keywords In situ, Phytate and Zinc.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Journal of dentistry), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.