Direct and indirect effects of Growth Hormone Deficiency (GHD) on lung function in children: A mediation analysis.

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this clinical trial publication.

For both aims the mediation analysis (MA) was applied to evaluate the extent to which the relationship between GHD and PFTs could be ascribed to a height-mediated (indirect) or a GH direct effect.

A MA was performed to assess the relationship between GHD and PFTs and height.

Why It Was Studied

Studies on pulmonary function tests (PFTs) in Growth Hormone Deficiency (GHD) children are lacking.

Who Took Part

According to the abstract, 47 children were involved.

The age groups tagged for this paper are children and teenagers, both men and women.

47 pre-pubertal GHD children (aged 5-14 years) underwent PFTs at T0 and T1.

At T0, 47 healthy children matched for age and sex were enrolled as Controls.

How the Study Was Run

Statistical analyses were performed using the statistical software R (https://cran.r-project.org/mirrors.html).

What Was Measured

Studies on pulmonary function tests (PFTs) in Growth Hormone Deficiency (GHD) children are lacking.

PubMed files the paper under topics including Carbon Monoxide, Dwarfism, Pituitary, Forced Expiratory Volume, Functional Residual Capacity, Growth Hormone, Human Growth Hormone and Italy.

Author keywords: Children, Growth-hormone-deficiency, Lung function tests and Mediation analysis.

What This Means in Plain Language

This is a clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 47 children.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Respiratory medicine), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.