The effect of intrauterine human chorionic gonadotropin flushing on live birth rate after vitrified-warmed embryo transfer in programmed cycles: a randomized clinical trial

What Was Tested

The paper reports a study of hCG (human chorionic gonadotropin), published as a randomized controlled trial.

To assess the influence of intrauterine human chorionic gonadotropin (hCG) before embryo transfer on the clinical pregnancy and live birth rates after vitrified-warmed embryo transfer (ET) in programmed cycles.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

This study was a single-blind randomized clinical trial for eligible patients underwent frozen ET cycles with long-term hormonal GnRH agonist protocol for endometrial preparation.

Immediately prior to ET, the women were randomly divided into three groups.

How the Study Was Run

In design terms this was a randomized and single-blind study.

The participants were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.

Only one side, usually the participants, was kept unaware of whether hCG (human chorionic gonadotropin) was given.

In the first control (sham) group, 7-10 min before ET just 40 μL of culture medium intrauterine was infused.

In the second control group, no intervention was done.

The pregnancy outcomes were compared in the three groups using appropriate statistical tests.

What Was Measured

Topics PubMed links to this paper include Abortion, Spontaneous, Administration, Intravaginal, Birth Rate, Chorionic Gonadotropin, Cryopreservation, Embryo Transfer and Iran.

Author keywords: Intrauterine human chorionic gonadotropin, Live birth rate, Randomized clinical trial and Vitrified-warmed embryo transfer.

What This Means in Plain Language

The paper is a randomized and single-blind study of hCG (human chorionic gonadotropin).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Archives of gynecology and obstetrics), a journal based in Germany.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.