Effect of one time high dose "stoss therapy" of vitamin D on glucose homeostasis in high risk obese adolescents.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

OGTTs to assess indices of sensitivity and secretion were done at baseline, 6 weeks and 12 weeks respectively.

Who Took Part

According to the abstract, 20 adolescents were involved.

PubMed indexes the participants as teenagers, both men and women.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and crossover study.

The adolescents were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Some adolescents received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.

In a randomized placebo controlled cross over design 20 obese adolescents with vitamin D deficiency (VDD) had baseline OGTT.

What Was Measured

Topics PubMed links to this paper include Blood Glucose, Body Mass Index, Ergocalciferols, Glucose Tolerance Test, Homeostasis, Insulin Resistance and Pediatric Obesity.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Vitamin D, K2, Magnesium and Zinc in 20 adolescents.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Archives of endocrinology and metabolism), a journal based in Brazil.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.